Causes of Arthritis
You may be interested to know about the cause of arthritis. You may be surprised to note that the true cause of arthritis is still not known to the medical authorities. It has been observed that the female population is more susceptible to develop arthritis and it surpasses male population by 3:1 ratio. Some clinical data suggest that the arthritis disorder is a hereditary transmitted disease and laboratory findings confirm that there is a deficiency of particular type of HLA or human leukocyte antigen in arthritis problem.
It has also been seen that in all cases of arthritis there is an inflammation or a disturbance of the semi liquid portion in between the bone joints and there is gradual reduction of the content, rendering two bones to have friction continuously during movement of the body. There is a development of an inflammatory membrane on the cartilage part of the bone joints. Cartilages are the special types of tissue that protects the bone from wasting. When this cartilage is eroding, it makes the bone cells naked in the susceptible areas and bone gets pained with the continuous frictional exposure while the body moves.
Clinical Picture or Arthritis
Laboratory examination confirms that there is a nodular appearance on the cartilage and it is in inflammatory condition. In most of the cases, the attack is triggered by emotional disturbance or by trauma or surgical intervention. The swelling of joints is generally associated with stiffness of the particular area. Many laboratory findings have confirmed that that is an abnormality of some protein structure. Some antibodies, responsible for defense mechanism become defective and notably IgM or IgG is the main to be blamed with. Old age is the significant risk factor.
Associated Aggravating Factors in Developing Arthritis
In some cases, arthritis can be a secondary development of syphilis sarcoidosis (one type of granulomatous disease that involves skin and lungs mainly along with other organs), tuberculosis or leprosy. In any case, the presence of auto antibody is demonstrable that inhibits the body’s antibody from fighting against the disorder. Some bacterial infections and viral infections also may give rise to arthritis.
Other Findings of the Disorder of Arthritis
It has been observed that female population outscores the male sex in the frequency of developing arthritis and the most vulnerable age group is between 20 to 45 years. The family history also plays a significant part in developing arthritis
